Quercetin improves memory problems in obese mice by activating a key cell pathway through the gut-brain connection

Quercetin supplementation at 0.05% significantly reduced HFFD-induced body weight gain in a 10-week mouse model.

• Quercetin improved serum lipid abnormalities and cognitive performance in obese mice.
• Dietary quercetin altered gut microbiota composition, notably increasing Akkermansia muciniphila.
• Restoration of intestinal barrier function was observed with quercetin supplementation.
• Quercetin regulated serum metabolite profiles and suppressed neuroinflammation.
• Activation of the hippocampal insulin signaling pathway was indicated by increased expression of p-PI3K, p-Akt, and p-GSK-3β.
• Quercetin inhibited abnormal tau phosphorylation and neuronal cell death.

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