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Design, synthesis and biological evaluation of novel quinoline‐based carboxylic hydrazides as anti‐tubercular agents
Creation and testing of new quinoline-based compounds as potential tuberculosis treatments
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Abstract
Four quinoline-based carboxylic hydrazides demonstrated significant anti-tubercular activity with MIC values below 20 μg/mL.
- The two most effective compounds, 6j and 6m, had MIC values of 7.70 and 7.13 μg/mL, respectively, against Mycobacterium tuberculosis.
- All tested compounds were evaluated for their cytotoxicity against human lung fibroblast cells.
- A structure-activity relationship analysis was conducted to understand how different substitutions affected anti-tubercular activity.
- These findings suggest potential for further development of these hydrazides as anti-tubercular agents.
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