Identification of a novel class of quinoline–oxadiazole hybrids as anti-tuberculosis agents

Dec 18, 2015Bioorganic & medicinal chemistry letters

Discovery of new quinoline-oxadiazole compounds that may fight tuberculosis

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Abstract

Several hybrid compounds exhibited minimum inhibitory concentration values <0.5 μM and selectivity index >500.

  • Novel quinoline-oxadiazole hybrid compounds were designed to enhance bioactivity.
  • The compounds were screened for activity against Mycobacterium tuberculosis H37Rv.
  • Good to excellent anti-tuberculosis activity was observed in multiple compounds.
  • Compounds 12m, 12o, and 12p demonstrated particularly strong activity and selectivity.
  • The findings suggest potential for developing a new class of anti-tuberculosis agents.

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