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Abstract
Several hybrid compounds exhibited minimum inhibitory concentration values <0.5 μM and selectivity index >500.
- Novel quinoline-oxadiazole hybrid compounds were designed to enhance bioactivity.
- The compounds were screened for activity against Mycobacterium tuberculosis H37Rv.
- Good to excellent anti-tuberculosis activity was observed in multiple compounds.
- Compounds 12m, 12o, and 12p demonstrated particularly strong activity and selectivity.
- The findings suggest potential for developing a new class of anti-tuberculosis agents.
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