Quinoline as a Privileged Scaffold in Cancer Drug Discovery

Quinoline compounds demonstrate effective anticancer activity, alongside their known anti-malarial and anti-microbial properties.

• Quinoline is a heterocyclic compound with a double-ring structure that enhances its synthetic versatility.
• These compounds are used to create numerous derivatives with potential medical benefits.
• Quinoline and its analogs may inhibit key processes involved in cancer progression, including tyrosine kinases and DNA repair.
• The review summarizes the anticancer activities of quinoline compounds, their mechanisms of action, and structure-activity relationships.
• In vitro and in vivo studies indicate specific anticancer effects related to various drug targets.

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