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How racial identity relates to brain scans and blood markers of Alzheimer's disease
Updated
Abstract
Significant differences in biomarker values were observed between 260 older adults racialized as Black and/or African American and non-Hispanic white.
- Global Pittsburgh Compound B (PiB) standardized uptake value ratio (SUVR) varied significantly between the two racialized groups.
- Cortical thickness measurements also showed notable differences across the groups.
- Levels of p-tau181 and p-tau231 differed significantly, suggesting variations in Alzheimer's disease pathology.
- These differences were consistent regardless of age, sex, genetic risk factors, education, or cognitive assessment scores.
- Racialization may need greater emphasis in Alzheimer's disease clinical research to ensure equitable assessments.
Simplified
Key numbers
2.68
Higher p-tau181 in AA participants
Mean p-tau181 level in AA participants (natural log transformed)
1.17
Higher in NHW participants
Mean in NHW participants (natural log transformed)
65.5
Age difference between groups
Mean age of AA participants in years