Randomized Trial of 2‐Dose versus Monthly Sulfadoxine‐Pyrimethamine Intermittent Preventive Treatment for Malaria in HIV‐Positive and HIV‐Negative Pregnant Women in Malawi

HIV-positive women receiving monthly sulfadoxine-pyrimethamine (SP) had 7.8% placental malaria compared to 21.5% in those receiving a 2-dose regimen.

• Monthly SP IPTp is associated with significantly lower rates of placental malaria in HIV-positive women compared to a 2-dose regimen.
• For HIV-negative women, monthly SP IPTp also shows lower rates of placental malaria compared to the 2-dose regimen, though the difference is less pronounced.
• Less than 1% of women reported adverse drug reactions, with no increase in reports among HIV-positive women or those receiving monthly SP.
• The findings suggest that monthly SP IPTp maintains efficacy in preventing placental malaria despite decreasing efficacy for treating malaria in children.

AI simplified