Targeted Delivery of Polyphenol Nanoparticles to Cell Membranes Using Receptor Binding for Alzheimer's Treatment

The optimized biomimetic nanostructure demonstrates 42.35% blood-brain barrier permeability.

• Polyphenol-based carbon dots (PCDs) have inherent antioxidant properties that may aid in Alzheimer's disease treatment.
• Conventional cell membrane coating techniques have limitations that can mask active sites and inactivate membrane proteins.
• The novel biomimetic nanostructure created by anchoring mannose-modified quercetin nanodots onto cell membrane fragments achieves 84.3% anchoring efficiency.
• This design allows for high blood-brain barrier permeability and precise targeting of BV2 cells.
• The released nanodots may regulate reactive oxygen species homeostasis, inhibit amyloid-β fibrillation, and promote amyloid-β autophagy.

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