Full text is available at the source.
Abstract
Redox-responsive lipid nanoparticles (LNPs) may enhance the delivery of therapeutic agents by utilizing disease-associated redox imbalances.
- These nanoparticles can trigger controlled release of cargo in response to elevated levels of glutathione and reactive oxygen species.
- Applications extend beyond nucleic acids to include small molecules, proteins, and theranostic agents, indicating broad therapeutic potential.
- Key challenges include variability in redox conditions, stability of the nanoparticles, and the complexity of translating these technologies to clinical use.
- Future research may focus on improving organ-selective delivery and developing multifunctional therapeutics using LNPs.
Simplified