Current opinion in oncology

Using psychedelic-assisted therapy to change how cancer-related distress is experienced

Updated

Abstract

Recent trials in advanced cancer populations report improvements in anxiety, depression, pain-related distress, and quality of life following one or two dosing sessions of psychedelic-assisted therapy.

  • Psychedelic-assisted therapy (PAT) combines psychedelic compounds with structured psychotherapeutic support.
  • PAT may enhance neuroplasticity and emotional flexibility, potentially supporting sustained psychological change.
  • Current evidence on PAT is limited by small sample sizes and narrow demographic representation.
  • Variable treatment protocols and potential expectancy effects could influence observed outcomes.
  • Practical challenges in implementation include the need for specialized training and resource intensity.

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