Partial cell reprogramming resembles natural tissue healing and may promote regeneration

Partial reprogramming can erase aging and damage features in cells, leading to increased healthspan, lifespan, and tissue regeneration.

• Transcription factors Oct4, Sox2, Klf4, and C-Myc (OSKM) are involved in the process of partial reprogramming.
• Partial reprogramming may share mechanisms with natural dedifferentiation and regeneration.
• Transient repression of somatic identity may occur through the sequestration of somatic identity transcription factors to noncanonical sites.
• High expression of pioneer transcription factors could lead to a temporary shift to a fetal-like state in cells.
• Epigenetic remodeling is proposed as a common mechanism between partial reprogramming and natural regeneration following tissue injury.

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