Regulation of basic helix‐loop‐helix transcription factors Dec1 and Dec2 by RORα and their roles in adipogenesis†

Jan 17, 2012Genes to cells : devoted to molecular & cellular mechanisms

Control of key gene regulators Dec1 and Dec2 by RORα and their roles in fat cell development

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Circadian BiologyCircadian Biology on OpenScience ↗PubMed ↗DOI ↗

Abstract

DEC1 and DEC2 expression is regulated by RORα, which may suppress adipogenic differentiation in 3T3-L1 adipocytes.

  • DEC1 and DEC2 are influenced by the CLOCK:BMAL1 complex, displaying a circadian rhythm in the suprachiasmatic nucleus.
  • Novel ROR response elements (RORE) were identified in the promoters of DEC1 and DEC2.
  • RORα activates DEC1 and DEC2 expression, while REVERBα does not have a significant effect.
  • RORα may inhibit adipogenic differentiation at a later stage by stimulating DEC1 and DEC2 expression.

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