How Sedation with Remifentanil Pain Relief May Affect Delirium in Critically Ill Patients
Updated
Abstract
The incidence of delirium was significantly lower in the observation group at 22.9% compared to 57.1% in the control group.
- Sedation combined with analgesia may lead to a lower dosage of midazolam used, which was 160.6 ± 33.3 mg/d in the observation group versus 178.9 ± 43.4 mg/d in the control group.
- The duration of delirium was slightly shorter in the observation group, averaging 162.9 ± 78.0 hours compared to 194.8 ± 117.3 hours in the control group.
- Patients with delirium in the observation group received significantly less dexmedetomidine, at 0.54 ± 0.11 mg/d versus 0.64 ± 0.14 mg/d in the control group.
- Mean arterial pressure (MAP) remained stable before and after sedation in both groups, with no significant differences.
- There were no significant differences in waking-up time, duration of mechanical ventilation, length of ICU stay, or 28-day fatality rates between the two groups.
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