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Two Ways Cells Remove Damaged Mitochondria: Breaking Down and Releasing Them
Updated
Abstract
Essence
Cardiomyocytes remove damaged mitochondria through degradation and extracellular vesicle secretion, pathways linked to cardiac disease and therapeutic targeting.
Evidence
Review summarizing mechanisms of mitochondrial degradation, mainly autophagy, and secretion via extracellular vesicles in the heart.
Caveat
Because it is a mechanistic review, it maps pathways and disease links rather than testing whether targeting either route improves cardiac outcomes.
Simplified
Longevity & Aging