Resistance training enhances components of the insulin signaling cascade in normal and high-fat-fed rodent skeletal muscle

Resistance training increased GLUT-4 protein concentration in the red gastrocnemius and quadriceps of both control and high-fat diet groups.

• Insulin-stimulated activity of insulin receptor substrate-1-associated phosphatidylinositol-3 kinase was enhanced in the red gastrocnemius and quadriceps of control and high-fat diet rats undergoing resistance training.
• Atypical PKC-zeta/lambda and Akt activities were reduced in the high-fat sedentary group but were normalized in the high-fat resistance training group.
• No differences were found in total protein concentrations of insulin receptor substrate-1, Akt, atypical PKC-zeta/lambda, or in the phosphorylation of Akt.
• Chronic resistance training may improve insulin-stimulated carbohydrate metabolism in normal skeletal muscle.
• Resistance training could reverse high-fat diet-induced insulin resistance by altering components of the insulin signaling cascade and glucose transporter system.

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