Resveratrol from grapes and its effects on stress hormone release and production in cow adrenal cells

Resveratrol inhibited catecholamine secretion with an IC(50) of 20.4 microM in cultured bovine adrenal medullary cells.

• Catecholamine secretion and synthesis were suppressed by resveratrol in a concentration-dependent manner.
• The compound reduced sodium and calcium ion influx triggered by acetylcholine and other activators.
• Resveratrol directly inhibited the current in neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes.
• It also diminished catecholamine synthesis induced by acetylcholine at an IC(50) of 5.32 microM.
• These findings suggest a mechanism where resveratrol may affect neurotransmitter release through ion channel modulation.

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