A multi-purpose dressing based on resveratrol-loaded ionic liquids/gelatin methacryloyl hydrogel for enhancing diabetic wound healing

Oct 23, 2024International journal of biological macromolecules

A versatile wound dressing with resveratrol that may improve healing in diabetic wounds

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Abstract

The ILs/GelMA@Res hydrogel promoted accelerated wound closure and enhanced neovascularization in a diabetic wound mice model.

The hydrogel demonstrated strong antibacterial activity against Staphylococcus aureus and Escherichia coli.
Sustained release of resveratrol from the hydrogel is linked to increased angiogenesis.
Activation of the PI3K/AKT signaling pathways associated with VEGF and FGF was observed.
Enhanced endothelial cell proliferation, migration, and tube formation were noted in vitro.
The hydrogel system exhibited desirable mechanical properties and biocompatibility.

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Diabetic wound (DW) is a multifaceted challenge, characterized by persistent bacterial infections and compromised angiogenesis. To address these issues and enhance DW healing, we developed a novel strategy using a photo-crosslinked hydrogel system composed of ionic liquids (ILs) and gelatin methacryloyl (GelMA) loaded with resveratrol (Res). The ILs/GelMA hydrogel was fabricated via a simple photo-crosslinking process, resulting in desirable mechanical properties, biocompatibility, and controlled release kinetics. Res was incorporated into the hydrogel matrix (ILs/GelMA@Res) to ensure sustained release, facilitating angiogenesis and accelerating wound healing. In vitro studies demonstrated that the ILs/GelMA@Res hydrogel exhibited potent antibacterial activity against Staphylococcus aureus and Escherichia coli, inhibiting bacterial growth and biofilm formation. Furthermore, the sustained release of Res from the hydrogel promoted angiogenesis by activating the PI3K/AKT signaling pathways associated with VEGF and FGF, enhancing endothelial cell proliferation, migration, and tube formation. In a DW mice model, the ILs/GelMA@Res hydrogel demonstrated accelerated wound closure, reduced inflammation, and robust neovascularization. This multifunctional hydrogel-based delivery system holds considerable potential for clinical translation, offering a safe and effective treatment modality for diabetic patients with chronic wounds.

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