Eating and weight disorders : EWDNov 29, 2025

Resveratrol supplements and their impact on obesity measures: an overview of intervention studies

Longevity & Aging Weekly Brief ↗PubMed ↗DOI ↗OA ↗

Updated Jun 28, 2026

Abstract

Essence

Resveratrol supplementation was linked to small reductions in body weight, BMI, waist circumference, and body fat in obesity-related intervention meta-analyses.

Evidence

This umbrella review synthesized 18 interventional meta-analyses and found small pooled improvements versus control, including -0.18 kg body weight, -0.14 kg/m BMI, -0.43 cm waist circumference, and -0.3 kg body fat.

Caveat

The effects were small and reached statistical significance only in subgroups using doses above 400 mg/day and interventions longer than 12 weeks.

Simplified

OBJECTIVE: Despite several studies assessing the impact of resveratrol on obesity indices, previous meta-analyses show conflicting results. Therefore, we conducted this critical umbrella review of interventional meta-analyses on the effect of resveratrol supplementation on body mass index (BMI), body weight (BW), waist circumference (WC), and body fat.

METHODS: Searches were conducted across multiple databases to identify all relevant meta-analyses up to September 30th, 2025. Reported pooled effect sizes (ESs) and 95% confidence intervals (CIs) were extracted from each included study and synthesized using a random-effects model. Methodological quality was assessed using the AMSTAR 2 tool.

RESULTS: Ultimately, 18 meta-analyses were included, with results showing a small but statistically significant reduction in BW (ES: - 0.18 kg, 95% CI - 0.32 to - 0.03, p = 0.02), BMI (ES: - 0.14 kg/m, 95% CI - 0.2 to - 0.08, p < 0.001), WC (ES - 0.43 cm, 95% CI - 0.64 to - 0.22, p < 0.001), and body fat (ES: - 0.3 kg, 95% CI - 0.48 to - 0.12, p = 0.001) in the resveratrol group compared to the control group, with subgroup analysis revealing statistical significance only in subgroups with doses > 400 mg/day and study duration ˃ 12 weeks. 2

CONCLUSION: Our review confirms that resveratrol supplementation reduces BW, BMI, WC, and body fat, particularly on doses > 400 mg/day and interventions lasting ˃12 weeks, with small effect sizes. Based on our findings, resveratrol supplementation could be considered as a complementary therapy in the management of obesity.

Key numbers

-0.18 kg

Weight Reduction

Body weight reduction in the resveratrol group compared to control.

-0.14 kg/m

Reduction

reduction in the resveratrol group compared to control.

-0.43 cm

Reduction

reduction in the resveratrol group compared to control.

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Resveratrol supplements and their impact on obesity measures: an overview of intervention studies

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