Resveratrol reduces radiation damage and oxidative stress in rats, possibly through activating the body's antioxidant defense system

Ionizing radiation generates reactive oxygen species, leading to oxidative imbalance and tissue injury.

• Reactive oxygen species are linked to tissue damage caused by ionizing radiation.
• The Nrf2-antioxidant response element pathway is important for regulating antioxidant gene expression.
• Resveratrol may act as a natural antioxidant with properties that reduce inflammation and scavenge reactive oxygen species.
• There are currently limited options for effective agents that can modulate the effects of radiation.

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