Toxicology mechanisms and methods

Resveratrol's role in reducing reproductive damage: evidence and underlying mechanisms

Updated

Abstract

Resveratrol treatment is associated with improved redox balance and reduced inflammatory responses in reproductive health.

  • RSV may help preserve cellular and mitochondrial integrity.
  • Treatment with RSV could attenuate apoptotic signaling in reproductive tissues.
  • Modulation of steroidogenic and reproductive functions is observed with RSV.
  • Nrf2-associated antioxidant responses and SIRT1-related signaling have been reported in experimental models.
  • Responses involving PI3K/Akt and NF-κB/JNK-c-Jun pathways are implicated in the protective effects of RSV.
  • Ferroptosis, autophagy, and AhR-associated signaling may contribute to RSV's effects in selected models.

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