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Resveratrol delays senescence of human dental pulp stem cells via activating the SIRT1-mitochondrial autophagy
Resveratrol may slow aging in human dental stem cells by activating a cell cleanup and energy control process
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Abstract
Resveratrol improved proliferation and delayed senescence in human dental pulp stem cells (hDPSCs).
- Age-related metabolic differences were identified in dental pulp tissues, associated with Resveratrol.
- In vitro experiments showed Resveratrol promoted osteogenic differentiation and enhanced mitochondrial function in senescent hDPSCs.
- Resveratrol reduced mitochondrial damage and oxidative stress in senescent hDPSCs.
- Silencing PINK1 or PGC-1α reversed the positive effects of Resveratrol on cell proliferation and osteogenesis.
- Blocking negated Resveratrol's benefits on mitochondrial quality control.
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