BiogerontologyOct 23, 2026

Resveratroloside reduces aging signs in cells by improving energy production and DNA organization

Longevity & Aging Weekly Brief ↗PubMed ↗DOI ↗

Updated Oct 24, 2026

Abstract

Resveratrol glucoside (R-glc) showed markedly reduced cytotoxicity compared to resveratrol (RSV).

R-glc effectively improved multiple signs of cellular aging at low concentrations.
Enhanced mitochondrial function was observed, indicated by increased oxidative phosphorylation and decreased reliance on glycolysis.
R-glc upregulated SIRT6, an enzyme associated with cellular health, and decreased H3K9 acetylation, suggesting better chromatin stability.
These findings support the potential of R-glc as a safer alternative for modulating age-related cellular changes.

Simplified

Cellular senescence is characterized by coordinated disruptions in mitochondrial function and epigenetic regulation, with perturbation of the mitochondria-chromatin axis emerging as a central hallmark of this process. Resveratrol (RSV) has been extensively investigated as a modulator of this axis; however, its clinical utility is constrained by dose-dependent cytotoxicity. Here, we evaluated the safety profile and anti-aging potential of resveratrol glucoside (R-glc), a glucosylated derivative of RSV. R-glc exhibited markedly reduced cytotoxicity compared to RSV and effectively attenuated multiple senescence-associated phenotypes at low concentrations. Mechanistically, R-glc enhanced mitochondrial function, as evidenced by increased oxidative phosphorylation and reduced glycolytic dependence. At the epigenetic level, R-glc upregulated the NAD⁺-dependent deacetylase SIRT6 and decreased histone H3 lysine 9 (H3K9) acetylation, indicating improved chromatin stability. Taken together, these findings identify R-glc as a safer and functionally effective modulator of the mitochondria-chromatin axis, supporting its potential as a clinically applicable intervention for age-related functional decline.

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Resveratroloside reduces aging signs in cells by improving energy production and DNA organization

Abstract

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