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The Retina-Attached SCN Slice Preparation: An In Vitro Mammalian Circadian Visual System
A lab model of the mammalian body clock system connected to the eye
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Abstract
A novel in vitro preparation maintains functional connectivity between the retinas and the suprachiasmatic nucleus (SCN).
- Light-evoked responses in the SCN are partly driven by the melanopsin photosensory system of intrinsically photosensitive retinal ganglion cells.
- SCN neurons exhibit light adaptation, indicating a modification in response to varying light levels.
- The preparation has been successfully generated from both rats and transgenic mice, suggesting broader applicability.
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