Retinal Origins of Circadian Photoregulation's Specialized Dynamic Range and Temporal Integration.

No SJR dataJan 8, 2026bioRxiv : the preprint server for biology

How the Eye Controls Daily Light Responses Using Its Unique Sensitivity and Timing

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Circadian Biology on OpenScience ↗PubMed ↗DOI ↗

Abstract

M1 intrinsically photosensitive retinal ganglion cells (ipRGCs) demonstrate varying balances of intrinsic and extrinsic light detection mechanisms.

M1 ipRGCs respond to light both directly via melanopsin and indirectly through rod and cone photoreceptors.
The variation in drive balance across M1 cells contributes to the overall range of circadian photoregulation.
M1s exhibit a level of temporal integration similar to behavioral responses observed in light sensitivity.
There is a connection between the pupillary light reflex and the light processing capabilities of M1s.
New bioluminescence-based methods facilitate the identification of photosensitive neurons without desensitization.

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The circadian clock allows organisms to anticipate environmental changes that are driven by the earth's rotation, and synchronizes with this cycle using light. The clock extracts relevant parameters of illumination, responding selectively to intensities at twilight and above, and to the number of photons counted over an extended time window. These hallmark properties are thought to manifest in the brain. Here, we report that they emerge within specific neurons of the eye. These M1 intrinsically photosensitive retinal ganglion cells (ipRGCs) detect light directly, using a receptor called melanopsin, and indirectly, through circuits driven by rod and cone photoreceptors. We find that the balance of intrinsic and extrinsic drives varies widely across M1s, and the population accounts for the dynamic range of circadian photoregulation. Both singly and collectively, M1s approach the level of temporal integration observed behaviorally. The cellular and behavioral levels match when the pupillary light reflex-another M1-driven function-shapes the light that M1s receive. This work reveals how the first steps of sensory processing are precisely formatted for specific tasks. It also introduces bioluminescence-based methods for identifying photosensitive neurons without desensitization, allowing their mechanistic study under physiological conditions. 1 2-8 9 10

Abstract

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