Human subjects: All authors have confirmed that this study did not involve human participants or tissue. Animal subjects: The Nagoya University Animal Care Committee Issued protocol number M230317-002, M240278-003, M250182-004. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: This work was partially supported by Grants-in-Aid for Scientific Research C (H.K.; 22K09810) and for young scientists (A.S.; 22K16949, and H.S.; 22K16968) from the Ministry of Education, Culture, Sports, Science and Technology (KAKENHI) (http://www.jsps.go.jp/); Takeda Science Foundation (H.K.); Bayer Retina Award Foundation (H.K.), Oyama Health Foundation (H.K.), and the Naito Foundation (A.S.). Financial relationships: Koji M Nishiguchi declare(s) a grant from JCR Pharmaceuticals, Santen, Novartis, Japan Alcon, AMO, Takara Bio, Takeda Pharmaceutical, Bayer, Rohto Nitten, Wakamoto, Senjyu, HOYA, Topcon, Kowa, Ritz medical, ABBVIE, TOMEY, Eisai, Mayo Corporation, Icon Inc., JAMCON, Japan Focus Co., Kyowaika Co., Handaya Co., Nippon Chem., Chugai. Hiroki Kaneko declare(s) a grant from Senju, AMO. Hiroki Kaneko declare(s) personal fees and support for attending meetings/travel, receipt of equipment/materials/drugs/medical writing/gifts from Santen, Bayer, Novartis, Senju, AMO, HOYA, Japan Alcon, Kirin Holdings Company, Mochida, Chugai. Koji M Nishiguchi declare(s) personal fees and support for attending meetings/travel, receipt of equipment/materials/drugs/medical writing/gifts from Chugai, Alcon, Bayer, Novartis, Santen, Kowa, Senjyu, Otsuka, Wakamoto. Ayana Suzumura declare(s) personal fees from Bayer, Santen, Novartis, Chugai, Senju. Hideyuki Shimizu declare(s) personal fees from Amgen. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.
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