Lack of REV-ERBα increases IL-33-driven lung inflammation and airway sensitivity in mice

Loss of REV-ERBα significantly increased the recruitment of immune cells in response to IL-33.

• REV-ERBα deficiency led to a marked increase in eosinophils, neutrophils, innate lymphoid cells, and Th2 lymphocytes in the lungs.
• Airway hyperresponsiveness was exacerbated in the absence of REV-ERBα following IL-33 exposure.
• Chemokines associated with type 2 inflammation were elevated in knockout mice lacking REV-ERBα.
• Circadian clock protein expression was altered in the absence of REV-ERBα.
• Enhanced IL-33/ST2 signaling and reduced epithelial barrier-associated proteins were observed in REV-ERBα deficient mice.

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