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Test of the reward/circadian rhythm dysregulation model of risk for bipolar spectrum disorders at a micro time scale using multilevel moderated mediation.
Testing how problems with reward and daily rhythm systems may increase short-term risk for bipolar disorders
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Abstract
In a study of 145 young adults, significant interactions were found indicating that high-reward sensitivity is linked to increased reward-relevant life events and social rhythm disruption.
- High-reward individuals reported experiencing more reward-relevant life events during the 20-day assessment.
- Social rhythm disruption (SRD) was associated with these reward-relevant life events in individuals with high-reward sensitivity.
- Moderated mediation analysis revealed a significant daily relationship between reward-relevant life events and depressive symptoms through SRD.
- No significant indirect effect or moderation by reward group was observed for hypomanic symptoms.
- Findings suggest that hypersensitivity to reward may exacerbate the impact of life events on social rhythm disruption, potentially leading to depressive symptoms.
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