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Rhythmic protein condensation in the circadian regulation of glycogen metabolism
Daily cycles of protein clumping linked to the body’s clock control of sugar storage
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Abstract
Glycogen synthase enzyme (GlgA) exhibits rhythmic condensation patterns in cyanobacteria.
- Circadian rhythms influence glycogen storage and metabolism in cyanobacteria.
- Condensed foci of GlgA appear during morning hours, inhibiting glycogen synthesis.
- Glycogen synthesis is coordinated with energy demand, peaking at dusk.
- The condensation of GlgA is regulated by the circadian clock, not by glycogen levels in the cell.
- These findings suggest a model where circadian control affects glycogen metabolism through enzyme spatial organization.
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