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Rhythms of risk: the intersection of clocks, cancer, and chronotherapy
Daily biological rhythms, cancer, and timed treatment strategies
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Abstract
Circadian clocks influence cell cycle, DNA repair, metabolism, and immune function, which are critical in cancer development.
- Disruption of circadian regulators can either promote or suppress cancer, depending on tumor type and biological context.
- This dual effect may result from changes in circadian physiology and direct interactions between clock components and cancer-related pathways.
- Integrating circadian biology into precision oncology could enhance treatment effectiveness and reduce side effects.
- Chronotherapy aims to optimize drug administration timing according to circadian rhythms to improve therapeutic outcomes.
- Cancer type-specific investigations are necessary to fully realize the benefits of chronotherapy in cancer treatment.
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