The RIG-I-like receptor family of immune proteins

RIG-I-like receptors (RLRs) are crucial RNA sensors in the innate immune defense against virus infections.

• RLRs detect specific features in viral RNAs, but can also sense host RNAs due to disruptions in RNA processing or localization.
• The function and stability of RLRs are regulated by various host proteins and post-translational modifications.
• Metabolic changes during virus infection may impact RLR signaling, while RLR responses could also affect host metabolism.
• There is increasing evidence that RLRs and host cell processes are interconnected.

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