RIPK3 may increase gum cell death and gum inflammation by disrupting cell cleanup

Periodontitis is associated with persistent inflammation, alveolar bone loss, and mitochondrial dysfunction.

• Alveolar bone loss occurs alongside inflammation in periodontitis.
• Mitochondrial dysfunction may contribute to fibroblast programmed cell death.
• Receptor-interacting protein kinase 3 (RIPK3) plays a role in regulating inflammation and cell fate.
• The relationship between RIPK3 and FUNDC1-associated mitophagy in periodontitis is not well understood.

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