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Abstract
Migraine is associated with gut dysbiosis and metabolic disturbances.
- The gut-brain axis may play a role in migraine pathophysiology.
- Gut microbiota and related metabolites could influence migraine through various pathways.
- Microbiota-derived metabolites, such as short-chain fatty acids and tryptophan-related compounds, may affect neuroimmune signaling.
- Current evidence indicates that gut dysbiosis may modulate neuroinflammatory pathways and central sensitization in migraine.
- Direct causal evidence linking gut microbiota to migraine in humans is limited.
- Interventions targeting gut microbiota may offer potential adjunctive strategies, although clinical evidence is currently heterogeneous.
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