S‐cone contribution to the acute melatonin suppression response in humans

Exposure to 415 nm monochromatic light results in melatonin suppression that can be approximated by a 2:1 combination of melanopsin and S-cone signals.

• Short wavelength light, particularly at 415 nm, shows a significant effect on melatonin suppression in healthy young males.
• Data indicate that single-opsin models do not effectively predict responses to 415 nm light exposure.
• An extended action spectrum for melatonin suppression better aligns with a combination of melanopsin and S-cone contributions than with existing single-opsin models.
• Responses to 30-minute light exposure differ from those observed in longer (90-minute) exposures, suggesting rapid decay of the S-cone contribution.

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