Timing of Melatonin Release in Saliva Linked to Physical Decline, Breathing Symptoms, and Survival in Early ALS

Salivary dim-light melatonin onset (DLMO) may be altered in early amyotrophic lateral sclerosis (plwALS).

• Circadian disturbances are noted in individuals with amyotrophic lateral sclerosis.
• Endogenous circadian phase timing and its significance in early stages of the disease are not well understood.
• The study aims to evaluate if DLMO can serve as an objective marker for circadian phase in early plwALS.
• Prognostic implications of altered DLMO in early plwALS are being assessed.

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