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Evaluation of salivary melatonin measurements for Dim Light Melatonin Onset calculations in patients with possible sleep–wake rhythm disorders
Using saliva melatonin to measure sleep-wake cycle timing in people with possible sleep rhythm problems
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Abstract
A total of 1848 diagnostic 5-point curves were obtained, with DLMO determined in 76.2% of cases.
- Dim Light Melatonin Onset (DLMO) is calculated from saliva samples collected at home.
- DLMO is associated with different age groups, showing an increase with age.
- Moderate correlations exist between DLMO measurements and sleep onset times from both polysomnography and sleep diaries.
- Pearson correlation coefficients were 0.514 for PSG sleep onset and 0.653 for diary-reported onset.
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