Astragalus saponin reduces brain oxidative stress and improves vascular dementia in rodents by affecting gut E. coli

Astragalus membranaceus may improve cognitive dysfunction associated with vascular dementia by regulating gut bacteria.

• Vascular dementia is linked to cognitive dysfunction caused by cerebrovascular diseases.
• Astragalus membranaceus is known for its antioxidative and cognitive-improving effects.
• Increased abundance of Escherichia coli is associated with cognitive dysfunction.
• The study explores how Astragalus membranaceus may impact E. coli along the gut-brain axis.

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