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Role of sarcopenia in Temporal progression trajectory of cardiometabolic diseases: a prospective study in UK biobank
How Muscle Loss May Affect the Progression of Heart and Metabolic Diseases Over Time
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Abstract
During a median follow-up of 13.1 years, 51,705 participants experienced at least one cardiometabolic disease (CMD).
- Participants with confirmed or severe had a 1.42 times higher risk of moving from no CMD to a single CMD.
- The risk of death for those with confirmed or severe sarcopenia was 2.08 times greater compared to those free of sarcopenia.
- Sarcopenia is associated with increased risk of progression from single CMD to (CMM), with a hazard ratio of 1.69.
- The transition from single CMD to death was also more likely for those with severe sarcopenia, showing a hazard ratio of 2.05.
- All three components of sarcopenia—handgrip strength, muscle mass, and gait speed—are linked to increased risks of transitions, particularly low gait speed.
- Lifestyle factors may modify the impact of sarcopenia on mortality-related transitions.
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Key numbers
1.42
Increase in risk of CMD from no CMD
Hazard ratio for confirmed/severe transitioning from no CMD to single CMD
2.08
Increase in risk of death
Hazard ratio for confirmed/severe related to mortality
13.1 years
Median follow-up duration
Duration over which participants were monitored for CMD progression and mortality