Sarcopenic obesity is more closely associated with knee osteoarthritis than is nonsarcopenic obesity: A cross‐sectional study

Nov 30, 2012Arthritis and rheumatism

Sarcopenic obesity is more strongly linked to knee osteoarthritis than obesity without muscle loss

AI simplified

Circadian Biology on OpenScience ↗PubMed ↗DOI ↗

Abstract

Sarcopenic obesity was associated with a 3.51 times higher likelihood of knee osteoarthritis compared to nonsarcopenic obesity.

Prevalence of body composition categories among participants was 83.5% normal, 4.3% sarcopenic nonobesity, 9.2% nonsarcopenic obesity, and 3.0% sarcopenic obesity.
Participants with sarcopenic obesity were older, had lower appendicular skeletal muscle mass, higher whole-body fat mass, and greater waist circumference compared to those with nonsarcopenic obesity.
No significant differences in body weight or BMI were observed between participants with sarcopenic obesity and those with nonsarcopenic obesity.
Sarcopenic nonobesity did not show a significant association with knee osteoarthritis.

AI simplified

OBJECTIVE: Sarcopenic obesity is a body composition category in which obesity is accompanied by low skeletal muscle mass, offsetting the increase in body weight caused by increased adipose tissue. The purpose of this study was to analyze the association between knee osteoarthritis (OA) and 4 different categories of body composition: normal, sarcopenic nonobesity, nonsarcopenic obesity, and sarcopenic obesity.

METHODS: This was a cross-sectional study using the data from 2,893 participants in the Fifth Korean National Health and Nutrition Examination Survey. Radiographic knee OA was defined as a Kellgren/Lawrence grade of ≥2. Appendicular skeletal muscle mass (ASM) and whole-body fat mass were measured using dual x-ray absorptiometry. Sarcopenia was defined as a skeletal muscle mass index (ASM/body weight [%]) below -2SD of the value in sex-matched young reference groups. Nonsarcopenic obesity was defined as a body mass index (BMI) ≥27.5 kg/m(2) .

RESULTS: The prevalence of each body composition category was as follows: 83.5% normal, 4.3% sarcopenic nonobesity, 9.2% nonsarcopenic obesity, and 3.0% sarcopenic obesity. Compared with nonsarcopenic obesity participants, participants with sarcopenic obesity were significantly older, had lower ASM, higher whole-body fat mass, and higher waist circumference. However, there was no significant difference in body weight or BMI. In multivariate analysis, sarcopenic obesity was more closely associated with radiographic knee OA (OR 3.51 [95% confidence interval (95% CI) 2.15-5.75]) than was nonsarcopenic obesity (OR 2.38 [95% CI 1.80-3.15]). Sarcopenic nonobesity showed no significant association with knee OA.

CONCLUSION: Sarcopenic obesity was more closely associated with knee OA than was nonsarcopenic obesity, although both groups had equivalent body weight. This finding supports the importance of the systemic metabolic effect of obesity in knee OA.

Full Text

Full text is available at the source.

View full text ↗

Sarcopenic obesity is more closely associated with knee osteoarthritis than is nonsarcopenic obesity: A cross‐sectional study

Abstract

Full Text

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the circadian biology brief

Abstract

Full Text

Related papers

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the circadian biology brief