Sarcopenic obesity and weight loss-induced muscle mass loss

Apr 29, 2025Current opinion in clinical nutrition and metabolic care

Muscle loss from weight loss in people with both obesity and low muscle mass

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Abstract

Weight loss induced by incretin-based obesity management medications results in a significant reduction in .

  • The impact of fat-free mass loss on and function is currently uncertain.
  • Adequate protein intake and resistance training are important for reducing fat-free mass loss during weight loss.
  • Digital health and telemedicine exercise programs may help maintain muscle health while losing weight.
  • The clinical importance of fat-free mass loss during weight reduction is still debated.
  • Future research should focus on improving diagnostic criteria for and evaluating long-term effects of fat-free mass reduction.

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Key numbers

9% of community-dwelling older adults
Prevalence of
Among adults aged at least 65 years.
20–40% of total weight loss
Loss During Weight Loss
Associated with .

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