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Abstract
Elevated levels of IgG2 and IgG4 are linked to an increased risk of breakthrough infection in vaccinated individuals during Omicron predominance.
- IgG subclass responses are influenced by the history of exposure to SARS-CoV-2, with prior infection affecting class switching.
- IgG4 shows broader reactivity to Omicron variants compared to IgG1.
- Circulating levels of IgG2 and IgG4 decay more slowly than those of IgG1.
- A correlation exists between IgG4 levels and the presence of antibodies that bind to specific receptors only in participants with lower levels of IgG1.
- Differences in IgG subclass profiles may impact antibody-mediated immunity after mRNA vaccination.
Simplified
mRNA Technology