Full text is available at the source.
First SARS-CoV-2 infection influences antibody type changes after mRNA vaccination
Updated
Abstract
Elevated levels of IgG2 and IgG4 are linked to an increased risk of breakthrough infection in vaccinated individuals during Omicron predominance.
- IgG subclass responses are influenced by the history of exposure to SARS-CoV-2, with prior infection affecting class switching.
- IgG4 shows broader reactivity to Omicron variants compared to IgG1.
- Circulating levels of IgG2 and IgG4 decay more slowly than those of IgG1.
- A correlation exists between IgG4 levels and the presence of antibodies that bind to specific receptors only in participants with lower levels of IgG1.
- Differences in IgG subclass profiles may impact antibody-mediated immunity after mRNA vaccination.
Simplified
mRNA Technology