Full text is available at the source.
Abstract
Senescent cells accumulate in aging tissues and secrete a complex array of bioactive factors that may drive chronic low-grade inflammation.
- Accumulation of senescent cells is associated with alterations in the surrounding tissue environment.
- Chronic signaling from these cells could contribute to age-related diseases by perpetuating inflammation.
- Bioactive factors released by senescent cells may damage nearby cells and disrupt immune balance.
- A three-dimensional framework of duality, vicious cycle, and tissue specificity is proposed to guide targeted therapies.
- Mechanisms influencing tissue function during aging are discussed, along with strategies to mitigate senescent cell effects.
Simplified