New Insights into Schaftoside: How It Works, Moves Through the Body, and Its Treatment Potential

Schaftoside is a flavonoid C-glycoside with a very low oral bioavailability.

• Schaftoside exhibits various pharmacological activities, including anti-inflammatory, hepatoprotective, antioxidant, and neuroprotective effects.
• These activities may be linked to its influence on cellular processes like cell death, stress responses, and related signaling pathways.
• In vitro and in vivo studies have demonstrated its biological effects in different pathological models.
• Preliminary formulation strategies, particularly drug delivery systems, show promise in improving its bioavailability, though evidence is limited.
• Toxicological findings suggest that schaftoside could have a relatively safe profile.
• Further research is needed to understand the relationship between schaftoside, chemosensitivity, and drug resistance.

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