Secretin receptor-deficient mice exhibit robust food anticipatory activity

Robust food anticipatory activities (FAAs) were observed in both wild-type and secretin receptor-deficient mice during restricted feeding and subsequent fasting.

• Food anticipatory activity (FAA) occurs in nocturnal rodents when food is restricted to a specific daytime meal.
• FAA is believed to be mediated by a food-entrainable oscillator (FEO) that operates independently of the suprachiasmatic nucleus (SCN).
• The role of secretin receptor signaling in the FEO was examined using secretin receptor-deficient mice.
• Both wild-type and secretin receptor-deficient mice exhibited similar robust FAAs during the study.
• These findings suggest that secretin receptor signaling is not necessary for the functioning of the FEO.

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