Moringa oleifera leaf extract selectively removes brain tumor cells aged by amyloid-beta

Treatment with 300 µg/mL Moringa oleifera leaf extract significantly reduced the number of senescent cells in an Alzheimer's disease model.

• Senescent cells in the ageing brain contribute to Alzheimer's disease progression by promoting inflammation and neurodegeneration.
• SH-SY5Y cells exposed to 20 µM amyloid-β oligomers displayed increased markers of cellular senescence.
• Moringa oleifera leaf extract reduced the expression of senescence-associated molecular markers in treated cells.
• The extract also induced cell death in senescent cells while decreasing the secretion of pro-inflammatory cytokines.
• These findings indicate that Moringa oleifera may target senescent cells and reduce inflammation in the context of Alzheimer's disease.

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