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Semaglutide Reduces Cardiomyocyte Damage Caused by High-Fat Through HSDL2
Semaglutide may reduce heart muscle cell damage caused by a high-fat diet through HSDL2
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Abstract
Obesity increased oxidative stress, which was alleviated by intervention with semaglutide.
- Semaglutide treatment may reduce glucose levels and weight in obese models.
- High-fat conditions resulted in increased inflammatory and oxidative stress markers in cardiomyocytes.
- The expression of hydroxysteroid dehydrogenase-like protein 2 () was down-regulated in response to semaglutide treatment.
- Palmitic acid-induced oxidative stress and autophagy levels were decreased in cardiomyocytes lacking the HSDL2 gene.
- These findings suggest a potential mechanism for semaglutide's protective effects against obesity-induced myocardial injury.
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Key numbers
30%
Body Weight Change
Reduction in body weight after semaglutide intervention.
P<0.01
Serum Insulin Level
Comparison of serum insulin levels between and groups.