Diabetes, obesity & metabolism

Weight loss with semaglutide in Danish adults: user traits, treatment hopes, and reported results

Updated

Abstract

A total of 1013 individuals were invited to participate, with 55% (n = 559) accepting the survey on SEMA-WL usage.

  • Users of SEMA-WL were predominantly female (78%, n = 434) and aged between 36-65 years (76%, n = 423).
  • The median of users at treatment initiation was 36 (interquartile range [IQR] 32-40).
  • Two in three users (70%, n = 393) personally requested their general practitioner to initiate treatment.
  • Almost half (46%, n = 258) of the users expected treatment for a limited time, while only 11% (n = 64) anticipated lifelong treatment.
  • Self-reported median weight loss was 5.3% (IQR 3.2-8.5) for users treated for less than 3 months, increasing to 17% (IQR 13-21) for those treated for over 5 months.
  • More than half of users (59%, n = 330) reported experiencing side effects, with nausea (35%, n = 193) and constipation (29%, n = 160) being the most common.

Simplified

Key numbers

434
Female Users
Total female participants among 559 users.
17%
Median Weight Loss After >5 Months
Self-reported weight loss for users treated for over 5 months.
330
Users Reporting Side Effects
Total users who experienced side effects out of 559.

Full Text

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Funding

Competing interests

The authors declare no conflict of interest. Anton Pottegård reports participation in research projects funded by Alcon, Almirall, Astellas, AstraZeneca, Boehringer‐Ingelheim, Novo Nordisk, Servier and LEO Pharma (all regulator‐mandated phase IV‐studies), and an unrestricted research grant from Novo Nordisk, all with funds paid to the institution where he was employed (no personal fees) and with no relation to the work reported in this article. Reimar W. Thomsen reports that he has given presentations and lectures on medical research (both with and without financial compensation) for various companies, including AstraZeneca, Bayer, Boehringer Ingelheim, Eli Lilly, Novo Nordisk and Sanofi. He reports no other personal conflicts of interest; however, the Department of Clinical Epidemiology, Aarhus University and Aarhus University Hospital receives funding for other studies from companies in the form of research grants to (and administered by) Aarhus University. None of these studies have any relation to the current study.
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