Journal of drug targetingSep 18, 2026

Aging Skin Cells Release Particles That Affect Skin Aging and Repair, Offering Potential Treatment Options

Longevity & Aging Weekly Brief ↗PubMed ↗DOI ↗

Updated Sep 19, 2026

Abstract

Senescent cells secrete senescence associated extracellular vesicles (SA-EVs) that may impair skin regeneration and contribute to chronic skin disorders.

SA-EVs are characterized by increased secretion rates, altered production processes, and selective cargo containing proinflammatory molecules.
The contents of SA-EVs include microRNAs, cytokines, mitochondrial DNA, and various noncoding RNAs.
SA-EVs can promote cellular senescence in neighboring cells, negatively affecting wound healing.
These vesicles are associated with the development of chronic wounds, diabetic ulcers, burns, pathological scarring, and skin aging.
Therapeutic approaches targeting SA-EVs include senolytic and senomorphic strategies, as well as regenerative mesenchymal stem cell-derived vesicles.

Simplified

Cellular senescence is an important factor which significantly impairs the homeostasis and regeneration capability of skin through causing chronic inflammation, degradation of the extracellular matrix, depletion of stem cells, and angiogenesis impairment. In addition to the already known senescence associated secretory phenotype (SASP), senescent cells secrete senescence associated extracellular vesicles (SA-EVs) serving as powerful signaling molecules. SA-EVs are distinguished by the increased secretion rates, altered biogenesis and selective cargo loading which include proinflammatory microRNAs, cytokines, mitochondrial DNA, EphA2 protein and noncoding RNAs (tRNAs, lncRNAs, snoRNAs). SA-EVs promote senescence in a paracrine manner, impair the wound healing process and contribute to the development of chronic wounds, diabetic ulcers, burns, pathological scarring, skin aging and other skin disorders. The treatment approaches which target the reduction of the SA-EV burden can be either senolytic or senomorphic while the application of regenerative mesenchymal stem cell-derived EVs and modified EV platforms as well as using the biomaterial assisted systems are promising therapeutic options.

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Aging Skin Cells Release Particles That Affect Skin Aging and Repair, Offering Potential Treatment Options

Abstract

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