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Abstract
The senescence-associated secretory phenotype (SASP) consists of a collection of inflammatory cytokines, chemokines, and growth factors released by senescent cells.
- Senescent cells are characterized by growth arrest while remaining metabolically active.
- Understanding SASP is important for insights into aging and age-related diseases such as cancer and Alzheimer's disease.
- Investigating SASP may help ensure the safety and effectiveness of induced pluripotent stem cell (iPSC)-derived therapies in regenerative medicine.
- A reproducible protocol for characterizing SASP in primary and iPSC-derived skin fibroblasts is provided through multiplex immunoassays.
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