Deconstructing senescence phenotypes in cells of the bone and bone marrow

Myeloid cells exhibit the strongest senescence profile among immune cells, but their senescence levels remain lower than mesenchymal stromal cells.

• Cellular senescence in mesenchymal cells is linked to age-related bone loss.
• Mesenchymal cells showed a significant senescence profile, making them vulnerable to targeted clearance.
• Selective removal of p16+ myeloid cells did not provide long-lasting protection against bone loss.
• The findings highlight the complexity of developing treatments aimed at clearing senescent cells in mixed cell types, such as those found in bone.

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