Distinct aging patterns and their controls in different human brain cell types

Human brain cell types showed distinct senescence signatures and regulators, with TFAP4 acting in a cell-type-dependent way.

This preclinical profiling study tested five human brain cell lines under chronic 5-Bromodeoxyuridine stress and validated selected findings in primary cells and toxin-induced models.

The work is based mainly on cell and model systems, so therapeutic relevance for human neurodegenerative disease remains indirect.