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Abstract
Senotherapies may provide new strategies to target senescent cells associated with chronic inflammation and age-related diseases.
- Cellular senescence helps control the growth of aged or damaged cells but can lead to chronic inflammation.
- Senescent cells acquire a specific secretory profile that contributes to cancer and dysfunction in tissues as people age.
- Types of senotherapies include senolytics, which eliminate senescent cells, and senomorphics, which suppress their harmful secretions.
- There is potential for combining senotherapies with existing cancer treatments to enhance their effectiveness.
- Challenges remain in translating senotherapy approaches into clinical practice.
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